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カタログ番号 | 製品名 | 別名 | ターゲット |
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T3474 | RO 46-8443 | Endothelin Receptor | |
RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition. | |||
T5329 | Trandolapril | Angiotensin-converting Enzyme (ACE) | |
Trandolapril is an orally administered angiotensin converting enzyme (ACE) inhibitor that is hydrolysed to the active diacid trandolaprilat. | |||
T3046 | BMY 7378 dihydrochloride | BMY7378 HCl | Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor |
BMY 7378 dihydrochloride (BMY7378 HCl) , α1D-adrenergic receptor antagonist, is a weak partial agonist/antagonist of 5-HT1A receptor. | |||
T23044 | N,N'-Dicyclohexylurea | DCU,1,3-Dicyclohexylurea,NSC 17013,Dicyclohexylurea,Dicyclohexylcarbodiamide,AURORA KA-3582 | Epoxide Hydrolase |
N,N'-Dicyclohexylurea (AURORA KA-3582) is a soluble epoxide hydrolase (sEH) inhibitor. | |||
T16329 | Nitroflurbiprofen | NO-flurbiprofen,Nitroxybutyl flurbiprofen,HCT 1206 | COX |
Nitroflurbiprofen (Nitroxybutyl flurbiprofen) is a NO-releasing COX inhibitor and modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats. | |||
T14942 | CGP48369 | RAAS | |
CGP48369 is a potent angiotensin II receptor antagonist with antihypertensive effects that enhances endothelium-dependent relaxation of coronary arteries in spontaneously hypertensive rats. | |||
T36506 | Tempone | 4-Oxo-tempo | |
Tempone is an aminooxyalkane that acts as a free radical scavenger and reacts with reactive oxygen species (ROS). Intravenous Tempone reduces mean arterial pressure in spontaneously hypertensive rats. | |||
T28482 | Firibastat | QGC 001,QGC-001,RB-150,RB150,QGC001,RB 150 | Aminopeptidase |
Firibastat (RB150) is a glutamyl aminopeptidase antagonist and an orally active brain penetrating prodrug of EC33. It is a first-in-class brain aminopeptidase A (APA) inhibitor with a Ki of 200 nM. Firibastat selectively... | |||
T27743 | KRH-594 free acid | WK14922K,WK-1492,WK-14922K,WK1492 | |
KRH-594 is a potent, specific and insurmountable AT1 receptor antagonist. KRH-594 ameliorates hyperlipidaemia and nephropathy in diabetic spontaneously hypertensive rats. KRH-594 prevents end-organ damage in stroke-pron... | |||
T71396 | FCE-24379 | ||
FCE-24379 is a selective antagonist of vascular serotonin receptors that has been shown to lowers blood pressure in hypertensive rats. | |||
T28039 | Milfasartan | LR-B081,LRB-081,LR-B-081,LRB 081,LR-B 081 | |
Milfasartan is a potent, selective antagonist of AT1 receptor with oral activity. It markedly lowers the blood-pressure in conscious renal and spontaneously hypertensive rats. | |||
T27306 | Fasidotril | BP 1137,BP1137,BP-1.137,BP1.137,BP-1137,BP 1.137 | |
Fasidotril is a NEP/ACE inhibitor. Fasidotril was an effective oral antihypertensive agent during chronic treatment in high-renin renovascular rats, normal-renin SHR, and low-renin DOCA-salt hypertensive rats and in pati... | |||
T38424 | (R)-Fadrozole | FAD286,(R)-CGS 16949A free base,(R)-Fadrozole | |
(R)-Fadrozole ((R)-CGS 16949A; FAD286) is a potent nonsteroidal inhibitor. (R)-Fadrozole also inhibits human placental aromatase (pIC 50 = 6.17) and aldosterone biosynthesis. (R)-Fadrozole reverses cardiac fibrosis in sp... | |||
T71065 | Quinapril-d5 | ||
Quinapril-d5 is intended for use as an internal standard for the quantification of quinapril by GC- or LC-MS. Quinapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor quinaprilat. In vivo, quinapr... | |||
TP1892 | γ1-MSH | ||
Endogenous melanocortin MC3 receptor agonist (pKi = 7.46) that displays ~ 40-fold selectivity over MC4. Increases the release of extracellular dopamine, which induces grooming and vertical activity (rearing) in rats. Exh... | |||
T12596 | (4E)-SUN9221 | 5-HT Receptor , Adrenergic Receptor | |
T79267 | Antihypertensive agent 3 | ||
Antihypertensive agent 3 (compound 4a), an angiotensin II receptor 1 antagonist, demonstrates antihypertensive activity in spontaneously hypertensive rats (SHRs) [1]. | |||
T63452 | Benidipine | ||
Benidipine is a potent, orally active calcium channel antagonist. benidipine increases endothelial nitric oxide synthase activity and improves coronary circulation in hypertensive rats. benidipine resists apoptosis in is... | |||
T36207 | Methylspinazarin | ||
Methylspinazarin is a naphthoquinone bacterial metabolite that has been found in Streptomyces and is an inhibitor of catechol O-methyltransferase (COMT; IC50 = 0.8 μg/ml).1 It is selective for COMT over tyrosine hydroxyl... | |||
T36720 | Deacetylforskolin | ||
Deacetylforskolin is a diterpene and a derivative of forskolin that has been found inC. forskohliiand has diverse biological activities.1,2,3,4It activates rat adipocyte adenylyl cyclase (IC50= 20 μM) and inhibits glucos... | |||
T75137 | BAY-747 | ||
BAY-747 (BAY 1165747) is an orally administered, brain-penetrant compound that stimulates soluble guanylate cyclase (sGC). It effectively counteracts memory impairments induced by L-NAME and improves cognitive performanc... | |||
T69598 | Isoproterenol-d7 HCl | ||
Isoproterenol-d7 is intended for use as an internal standard for the quantification of isoproterenol by GC- or LC-MS. Isoproterenol is an agonist of β1- and β2-adrenergic receptors (β1- and β2-ARs; Kis = 224 and 458 nM, ... | |||
T70883 | Moexipril-d5 | ||
Moexipril-d5 intended for use as an internal standard for the quantification of moexipril by GC- or LC-MS. Moexipril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor moexiprilat. It is converted to ... | |||
T35591 | Guanfacine-13C,15N3 | Guanfacine-13C,15N3 | |
Guanfacine-13C,15N3is intended for us as an internal standard for the quantification of guanfacine by GC- or LC-MS. Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with Kivalues of 93, 1,380, and 3,890 nM for α2A... | |||
T37496 | Alamandine | ||
Alamandine can be formed from angiotensin A by action of ACE-2 or directly from angiotensin-(1-7) by decarboxylation of its aspartate residue. The angiotensin A analog produces effects resembling those of Ang II (1-7). H... | |||
T36565 | Adrenomedullin (13-52) (human) (trifluoroacetate salt) | ||
Adrenomedullin (13-52) is a truncated form of adrenomedullin (1-52) . It induces nitric oxide-dependent relaxation of and inhibits release of angiotensin II and endothelin-1 from isolated rat aorta. In vivo, adrenomedull... | |||
T68616 | Pentoprilat | ||
Pentoprilat is a member of a series of l-glutarylindoline-2(S)-carboxylic acid derivatives. Pentopril was evaluated as an inhibitor of a cell-free preparation of angiotensin-converting enzyme (ACE) isolated from rabbit l... | |||
T35876 | Chlorthalidone Impurity G | ||
Chlorthalidone impurity G is a potential impurity found in commercial preparations of chlorthalidone that has moderate antihypertensive effects. Chlorthalidone is a thiazide-like diuretic that inhibits the Na+/Cl- cotran... | |||
T36643 | PKI-166 hydrochloride | ||
Potent EGFR-kinase inhibitor (IC50 = 0.7 nM). Displays >3000-fold selectivity against a panel of serine/threonine kinases. Reduces metastasis and angiogenesis in a mouse model of pancreatic cancer. Antihypertensive and o... | |||
T83688 | R 715 TFA | [Ac-Lys-[D-βNal7,Ile8]des-Arg9]-BK,Ac-Lys-Arg-Pro-Pro-Gly-Phe-Ser-D2Nal-Ile-OH | |
R 715, a bradykinin B1 receptor antagonist, inhibits contractions in isolated human umbilical cords that express bradykinin B1 receptors (pA2 = 8.49). When administered at doses of 200, 400, and 600 µg/kg, R 715 enhances... |
カタログ番号 | 製品名 | 別名 | ターゲット |
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TN2990 | 3alpha-dihydrocadambine | Others | |
3alpha-Dihydrocadambine exhibits dose-dependent hypotensive and anti-hypertensive effects in anesthetized normotensive rats and in conscious spontaneously hypertensive rats. |